Dl-3-n-Butylphthalide Treatment Enhances Hemodynamics and Ameliorates Memory Deficits in Rats with Chronic Cerebral Hypoperfusion

Dl-3-n-Butylphthalide Treatment Enhances Hemodynamics and Ameliorates Memory Deficits in Rats with Chronic Cerebral Hypoperfusion

Our previous study has revealed that chronic cerebral hypoperfusion (CCH) activates a compensatory vascular mechanism attempting to maintain an optimal cerebral blood flow (CBF). However, this compensation fails to prevent neuronal death and cognitive impairment because neurons die prior to the rest...

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Bibliographic Details
Main Authors: Zhilin Xiong, Weibiao Lu, Lihui Zhu, Ling Zeng, Changzheng Shi, Zhen Jing, Yonghui Xiang, Wenxian Li, Chi Kwan Tsang, Yiwen Ruan, Li’an Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
DL-3-n-butylphthalide
bilateral common carotid artery occlusion
MRI
cerebral blood flow
vertebral artery
angiogenesis
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00238/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00238/full

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