18β-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK–TRAF6 Interactions and NF-κB and MAPK Signaling Pathways

18β-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK–TRAF6 Interactions and NF-κB and MAPK Signaling Pathways

Bone metabolism is determined by a delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts. The imbalance due to over-activated osteoclasts plays an important role in various diseases. Activation of NF-κB and MAPK signaling pathways by receptor activator of nuclear...

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Bibliographic Details
Main Authors: Xiao Chen, Xin Zhi, Zhifeng Yin, Xiaoqun Li, Longjuan Qin, Zili Qiu, Jiacan Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
18β-glycyrrhetinic acid
osteoclastogenesis
RANKL
TRAF6
MAPK signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00647/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00647/full

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