Jatrorrhizine Hydrochloride Suppresses RANKL-Induced Osteoclastogenesis and Protects against Wear Particle-Induced Osteolysis

Jatrorrhizine Hydrochloride Suppresses RANKL-Induced Osteoclastogenesis and Protects against Wear Particle-Induced Osteolysis

Wear particle-induced aseptic prosthetic loosening is a major complication associated with total joint arthroplasty (TJA). A growing body of evidence suggests that receptor activator of nuclear factor κ-B ligand (RANKL)-stimulated osteoclastogenesis and bone resorption are responsible for p...

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Bibliographic Details
Main Authors: Hui Li, Jing Wang, Qiwen Sun, Gang Chen, Shengnan Sun, Xuemei Ma, Haiwen Qiu, Xuerong Liu, Liangyi Xu, Mei Liu
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
jatrorrhizine hydrochloride
osteoclast formation
bone resorption
wear particle-induced osteolysis
MAPK signaling pathway
Online Access:https://www.mdpi.com/1422-0067/19/11/3698

Internet

https://www.mdpi.com/1422-0067/19/11/3698

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