Advances in the Signaling Pathways Downstream of Glial-Scar Axon Growth Inhibitors

Advances in the Signaling Pathways Downstream of Glial-Scar Axon Growth Inhibitors

Axon growth inhibitors generated by reactive glial scars play an important role in failure of axon regeneration after CNS injury in mature mammals. Among the inhibitory factors, chondroitin sulfate proteoglycans (CSPGs) are potent suppressors of axon regeneration and are important molecular targets...

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Bibliographic Details
Main Authors: Armin Sami, Michael E. Selzer, Shuxin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
scar inhibition
CSPG receptor
LAR
PTPσ
axon regeneration
intracellular signaling
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00174/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00174/full

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