Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses

The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence of the CD4 receptor at the cell surface, primary Envs sample a “closed” conformation that occludes CD4-induced (CD4i) epi...

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Bibliographic Details
Main Authors: Jonathan Richard, Jéréémie Prééévost, Amy E. Baxter, Benjamin von Bredow, Shilei Ding, Halima Medjahed, Gloria G. Delgado, Nathalie Brassard, Christina M. Sturzel, Frank Kirchhoff, Beatrice H. Hahn, Matthew S. Parsons, Daniel E. Kaufmann, David T. Evans, Andréééés Finzi, Stephen P. Goff
Format: Article
Language:English
Published: American Society for Microbiology 2018-03-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/9/2/e00358-18

Internet

http://mbio.asm.org/cgi/content/full/9/2/e00358-18

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