Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses
The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence of the CD4 receptor at the cell surface, primary Envs sample a “closed” conformation that occludes CD4-induced (CD4i) epi...
Main Authors: | Jonathan Richard, Jéréémie Prééévost, Amy E. Baxter, Benjamin von Bredow, Shilei Ding, Halima Medjahed, Gloria G. Delgado, Nathalie Brassard, Christina M. Sturzel, Frank Kirchhoff, Beatrice H. Hahn, Matthew S. Parsons, Daniel E. Kaufmann, David T. Evans, Andréééés Finzi, Stephen P. Goff |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2018-03-01
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Series: | mBio |
Online Access: | http://mbio.asm.org/cgi/content/full/9/2/e00358-18 |
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