Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition

Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition

During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell-derived CD34+ cells. The resulting transcripti...

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Bibliographic Details
Main Authors: Carolina Guibentif, Roger Emanuel Rönn, Charlotta Böiers, Stefan Lang, Shobhit Saxena, Shamit Soneji, Tariq Enver, Göran Karlsson, Niels-Bjarne Woods
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
endothelial-to-hematopoietic transition
developmental hematopoiesis
human induced pluripotent stem cells
hematopoietic stem cell
single cell analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303558

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http://www.sciencedirect.com/science/article/pii/S2211124717303558

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