A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

Curative cancer therapies are uncommon and nearly always involve multi-drug combinations developed by experimentation in humans; unfortunately, the mechanistic basis for the success of such combinations has rarely been investigated in detail, obscuring lessons learned. Here, we use isobologram analy...

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Bibliographic Details
Main Authors: Adam C Palmer, Christopher Chidley, Peter K Sorger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/50036