A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma

A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma

Abstract Background The mitochondrial protein p32 is a validated therapeutic target of cancer overexpressed in glioma. Therapeutic targeting of p32 with monoclonal antibody or p32-binding LyP-1 tumor-homing peptide can limit tumor growth. However, these agents do not specifically target mitochondria...

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Bibliographic Details
Main Authors: Venkata Yenugonda, Natsuko Nomura, Valentina Kouznetsova, Igor Tsigelny, Valentina Fogal, Elmar Nurmemmedov, Santosh Kesari, Ivan Babic
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Translational Medicine
Subjects:
Mitochondrial p32
C1qBP
Glioma
Metabolism
Pharmacophore modeling
Online Access:http://link.springer.com/article/10.1186/s12967-017-1312-7

Internet

http://link.springer.com/article/10.1186/s12967-017-1312-7

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