Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo

Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo

Abstract Background Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential mechanism for patients receiving chemo...

Full description

Bibliographic Details
Main Authors: Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Qi Qiu, Haiyan Lin, Qingxue Zhang
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Ovarian Research
Subjects:
Primordial follicle
Rapamycin
Cyclophosphamide
PI3K/Akt/mTOR
Online Access:http://link.springer.com/article/10.1186/s13048-017-0350-3

Internet

http://link.springer.com/article/10.1186/s13048-017-0350-3

Similar Items