Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor

Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor

Most nuclear receptors (NRs) bind DNA as dimers, either as hetero- or as homodimers on DNA sequences organized as two half-sites with specific orientation and spacing. The dimerization of NRs on their cognate response elements (REs) involves specific protein–DNA and protein–protein interactions. The...

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Bibliographic Details
Main Authors: Kareem Mohideen-Abdul, Karima Tazibt, Maxime Bourguet, Isabelle Hazemann, Isabelle Lebars, Maria Takacs, Sarah Cianférani, Bruno P. Klaholz, Dino Moras, Isabelle M. L. Billas
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Endocrinology
Subjects:
nuclear receptors
estrogen-related receptor
homodimerization
steroid receptors
DNA recognition
DNA shape
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00140/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00140/full

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