Quercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin

Quercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin

Objective(s):The colorectal cancer stem cells (CSCs) with the CD133+ phenotype are a rare fraction of cancer cells with the ability of self-renewal, unlimited proliferation and resistance to treatment. Quercetin has anticancer effects with the advantage of exhibiting low side effects. Therefore, we...

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Bibliographic Details
Main Authors: Shekoufeh Atashpour, Shamileh Fouladdel, Tahereh Komeili Movahhed, Elmira Barzegar, Mohammad Hossein Ghahremani, Seyed Nasser Ostad, Ebrahim Azizi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2015-07-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Apoptosis
Cancer stem cells
Cell cycle
Doxorubicin
Drug resistance
Quercetin
Online Access:http://ijbms.mums.ac.ir/pdf_4643_1fbe96eda4938c78b7e9da5f5fe9ae63.html

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http://ijbms.mums.ac.ir/pdf_4643_1fbe96eda4938c78b7e9da5f5fe9ae63.html

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