Local estrogen axis in the human bone microenvironment regulates estrogen receptor-positive breast cancer cells

Local estrogen axis in the human bone microenvironment regulates estrogen receptor-positive breast cancer cells

Abstract Background Approximately 70% of all breast cancers express the estrogen receptor, and are regulated by estrogen. While the ovaries are the primary source of estrogen in premenopausal women, most breast cancer is diagnosed following menopause, when systemic levels of this hormone decline. Es...

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Bibliographic Details
Main Authors: Derek F. Amanatullah, John S. Tamaresis, Pauline Chu, Michael H. Bachmann, Nhat M. Hoang, Deborah Collyar, Aaron T. Mayer, Robert B. West, William J. Maloney, Christopher H. Contag, Bonnie L. King
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Breast Cancer Research
Subjects:
Estrogen receptor positive breast cancer
Breast cancer metastasis to bone
Aromatase
Aromatase inhibitors
Bone tissue culture
Online Access:http://link.springer.com/article/10.1186/s13058-017-0910-x

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http://link.springer.com/article/10.1186/s13058-017-0910-x

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