Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation

Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation

The six-transmembrane protein of prostate 2 (Stamp2) acts as an anti-inflammatory protein in macrophages by protecting from overt inflammatory signaling and Stamp2 deficiency accelerates atherosclerosis in mice. Herein, we describe an unexpected role of Stamp2 in polymorphonuclear neutrophils (PMN)...

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Bibliographic Details
Main Authors: Martin Mollenhauer, Senai Bokredenghel, Simon Geißen, Anna Klinke, Tobias Morstadt, Merve Torun, Sabrina Strauch, Wibke Schumacher, Martina Maass, Jürgen Konradi, Vera B. M. Peters, Eva Berghausen, Marius Vantler, Stephan Rosenkranz, Dennis Mehrkens, Simon Braumann, Felix Nettersheim, Alexander Hof, Sakine Simsekyilmaz, Holger Winkels, Volker Rudolph, Stephan Baldus, Matti Adam, Henrik ten Freyhaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
six-transmembrane protein of prostate 2
Stamp2
Steap4
myocardial infarction
ischemia and reperfusion damage
left ventricular dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.701721/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.701721/full

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