Autism-associated Nf1 deficiency disrupts corticocortical and corticostriatal functional connectivity in human and mouse

Autism-associated Nf1 deficiency disrupts corticocortical and corticostriatal functional connectivity in human and mouse

Children with the autosomal dominant single gene disorder, neurofibromatosis type 1 (NF1), display multiple structural and functional changes in the central nervous system, resulting in neuropsychological cognitive abnormalities. Here we assessed the pathological functional organization that may und...

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Bibliographic Details
Main Authors: Ben Shofty, Eyal Bergmann, Gil Zur, Jad Asleh, Noam Bosak, Alexandra Kavushansky, F. Xavier Castellanos, Liat Ben-Sira, Roger J. Packer, Gilbert L. Vezina, Shlomi Constantini, Maria T. Acosta, Itamar Kahn
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Neurofibromatosis type 1
Autism
ADHD
fMRI
Mouse model
Pediatric patients
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301305

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http://www.sciencedirect.com/science/article/pii/S0969996119301305

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