Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation

Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation

Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs. Two DLBCL subtypes based on cell of origin are generally recognized, germinal center B (GCB)-like and activated B cell (ABC)-like. A pilot study to characterize the transc...

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Bibliographic Details
Main Authors: Ying Wu, Yu-Mei Chang, Gerry Polton, Anneliese J. Stell, Balazs Szladovits, Michael Macfarlane, Laureen M. Peters, Simon L. Priestnall, Nicholas J. Bacon, Kelvin Kow, Sarah Stewart, Eshita Sharma, Michelle R. Goulart, John Gribben, Dong Xia, Oliver A. Garden
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
diffuse large B cell lymphoma
dog
animal model
gene expression
metabolism
oxidative phosphorylation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00307/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00307/full

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