SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

Abstract Background Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated fatty acids via stearoyl-CoA desaturases (SCD) for regulating metabolic and signaling platforms. SCD1 overexpression functions as an oncogene in lung c...

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Bibliographic Details
Main Authors: Kelin She, Shenghua Fang, Wei Du, Xingxing Fan, Jiaxi He, Hui Pan, Liyan Huang, Ping He, Jun Huang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Cell International
Subjects:
SCD1
EGFR
AKT
EMT
Lung cancer
Online Access:http://link.springer.com/article/10.1186/s12935-019-0809-y

Internet

http://link.springer.com/article/10.1186/s12935-019-0809-y

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