MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation.

MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation.

The ETS-family transcription factors Ets1 and Ets2 are evolutionarily conserved effectors of the RAS/ERK signaling pathway, but their function in Ras cellular transformation and biology remains unclear. Taking advantage of Ets1 and Ets2 mouse models to generate Ets1/Ets2 double knockout mouse embryo...

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Bibliographic Details
Main Authors: Mohamed Kabbout, Duaa Dakhlallah, Sudarshana Sharma, Agnieszka Bronisz, Ruchika Srinivasan, Melissa Piper, Clay B Marsh, Michael C Ostrowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4072627?pdf=render

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http://europepmc.org/articles/PMC4072627?pdf=render

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