Lactoferrin is a dynamic protein in human melioidosis and is a TLR4-dependent driver of TNF-α release in Burkholderia thailandensis infection in vitro.

Lactoferrin is a dynamic protein in human melioidosis and is a TLR4-dependent driver of TNF-α release in Burkholderia thailandensis infection in vitro.

Melioidosis is an often-severe tropical infection caused by Burkholderia pseudomallei (Bp) with high associated morbidity and mortality. Burkholderia thailandensis (Bt) is a closely related surrogate that does not require BSL-3 conditions for study. Lactoferrin is an iron-binding glycoprotein that c...

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Bibliographic Details
Main Authors: Shelton W Wright, Lara Lovelace-Macon, Deirdre Ducken, Sarunporn Tandhavanant, Prapit Teparrukkul, Viriya Hantrakun, Direk Limmathurotsakul, Narisara Chantratita, T Eoin West
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0008495

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https://doi.org/10.1371/journal.pntd.0008495

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