A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells.

A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells.

BACKGROUND:Stromal-Derived Inducing Activity (SDIA) is one of the most efficient methods of generating dopaminergic (DA) neurons from embryonic stem cells (ESC). DA neuron induction can be achieved by co-culturing ESC with the mouse stromal cell lines PA6 or MS5. The molecular nature of this effect,...

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Bibliographic Details
Main Authors: Tandis Vazin, Kevin G Becker, Jia Chen, Charles E Spivak, Carl R Lupica, Yongqing Zhang, Lila Worden, William J Freed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2719871?pdf=render

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http://europepmc.org/articles/PMC2719871?pdf=render

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