CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells

CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells

Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent stem cells (iPSCs). All reprogramming methods are accompanied by the induction of DNA damage, of which double-strand breaks are the most cytotoxic and mutagenic. Consequently, DNA repair genes seem...

Full description

Bibliographic Details
Main Authors: Daniel Gómez-Cabello, Cintia Checa-Rodríguez, María Abad, Manuel Serrano, Pablo Huertas
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Stem Cell Reports
Subjects:
iPSC
cell reprogramming
genetic instability
DNA resection
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116302995

Internet

http://www.sciencedirect.com/science/article/pii/S2213671116302995

Similar Items