HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome

HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by maternal mutation and paternal imprinting of the gene encoding UBE3A, an E3 ubiquitin ligase. Although several potential target proteins of UBE3A have been reported, how these proteins regulate neuronal development remains uncl...

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Bibliographic Details
Main Authors: Tingting Wang, Jingyu Wang, Jie Wang, Lin Mao, Bin Tang, Peter W. Vanderklish, Xun Liao, Zhi-Qi Xiong, Lujian Liao
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Neurobiology of Disease
Subjects:
UBE3A
HAP1
Angelman syndrome
autophagy
SILAM
Proteome
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302530

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http://www.sciencedirect.com/science/article/pii/S0969996119302530

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