PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli

Abstract Cyclic AMP receptor protein (CRP), a global regulator in Escherichia coli, regulates more than 180 genes via two roles: activation and repression. Few methods are available for predicting the regulatory roles from the binding sites of transcription factors. This work proposes an accurate me...

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Bibliographic Details
Main Authors: Ming-Ju Tsai, Jyun-Rong Wang, Chi-Dung Yang, Kuo-Ching Kao, Wen-Lin Huang, Hsi-Yuan Huang, Ching-Ping Tseng, Hsien-Da Huang, Shinn-Ying Ho
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-18648-5