Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens.

Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens.

Reports have shown that activation of tumor-specific CD4(+) helper T (Th) cells is crucial for effective anti-tumor immunity and identification of Th-cell epitopes is critical for peptide vaccine-based cancer immunotherapy. Although computer algorithms are available to predict peptides with high bin...

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Bibliographic Details
Main Authors: Junji Yatsuda, Atsushi Irie, Kumiko Harada, Yayoi Michibata, Hirotake Tsukamoto, Satoru Senju, Yusuke Tomita, Akira Yuno, Masatoshi Hirayama, Mohammad Abu Sayem, Naoki Takeda, Isao Shibuya, Shinji Sogo, Fumihiro Fujiki, Haruo Sugiyama, Masatoshi Eto, Yasuharu Nishimura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3875545?pdf=render

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http://europepmc.org/articles/PMC3875545?pdf=render

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