A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

Abstract Background Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency of mRNA translation and define their contribution to the development...

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Bibliographic Details
Main Authors: Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Genome Biology
Subjects:
Genetic variation
trans QTL mapping
Translational efficiency
Ribosome profiling
Cardiac hypertrophy
Ribosome biogenesis
Online Access:https://doi.org/10.1186/s13059-021-02397-w

Internet

https://doi.org/10.1186/s13059-021-02397-w

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