BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development.
Craniofacial abnormalities, including facial skeletal defects, comprise approximately one-third of all birth defects in humans. Since most bones in the face derive from cranial neural crest cells (CNCCs), which are multipotent stem cells, craniofacial bone disorders are largely attributed to defects...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-05-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5951594?pdf=render |