Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2
The free fatty acid-mediated inflammatory activities are regulated through TLR4. Here the authors show that palmitic acid binds to MD2, initiating complex formation with TLR4, recruitment of MyD88, and subsequent activation of pro-inflammatory molecules, and that MD2 blockade protects against diet-i...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13997 |