Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.
Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways. Population-based analyses of clinically derived HIV sequences may be used to identify immu...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-07-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC1904471?pdf=render |