Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.

Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways. Population-based analyses of clinically derived HIV sequences may be used to identify immu...

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Bibliographic Details
Main Authors: Zabrina L Brumme, Chanson J Brumme, David Heckerman, Bette T Korber, Marcus Daniels, Jonathan Carlson, Carl Kadie, Tanmoy Bhattacharya, Celia Chui, James Szinger, Theresa Mo, Robert S Hogg, Julio S G Montaner, Nicole Frahm, Christian Brander, Bruce D Walker, P Richard Harrigan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC1904471?pdf=render

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http://europepmc.org/articles/PMC1904471?pdf=render

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