Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix

Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix

The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix to deliver methotrexate (MTX) to colon. The primed Gel/PVA hydrogels were subjected to evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic and porosity using an acidic (pH 1.2) and phosphate...

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Bibliographic Details
Main Authors: Muhammad Akhlaq, Abul Kalam Azad, Inam Ullah, Asif Nawaz, Muhammad Safdar, Tanima Bhattacharya, A. B. M. Helal Uddin, Syed Atif Abbas, Allan Mathews, Sukalyan Kumar Kundu, Mireia Mallandrich Miret, H. C. Ananda Murthy, H. P. Nagaswarupa
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Polymers
Subjects:
methotrexate
gelatin
polyvinyl alcohol
hydrogel
pH-responsive
targeted delivery
Online Access:https://www.mdpi.com/2073-4360/13/14/2300

Internet

https://www.mdpi.com/2073-4360/13/14/2300

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