Leonurine Promotes the Osteoblast Differentiation of Rat BMSCs by Activation of Autophagy via the PI3K/Akt/mTOR Pathway

Leonurine Promotes the Osteoblast Differentiation of Rat BMSCs by Activation of Autophagy via the PI3K/Akt/mTOR Pathway

BackgroundLeonurine, a major bioactive component from Herba leonuri, has been shown to exhibit anti-inflammatory and antioxidant effects. The aim of this study was to investigate the effect of leonurine on bone marrow-derived mesenchymal stem cells (BMSCs) as a therapeutic approach for treating oste...

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Bibliographic Details
Main Authors: Bingkun Zhao, Qian Peng, Enoch Hin Lok Poon, Fubo Chen, Rong Zhou, Guangwei Shang, Dan Wang, Yuanzhi Xu, Raorao Wang, Shengcai Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
BMSCs
leonurine
autophagy
osteoporosis
PI3K/Akt/mTOR pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.615191/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2021.615191/full

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