Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity

Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity

A novel series of quinoline derivatives of combretastatin A-4 incorporating rigid hydrazone and a cyclic oxadiazole linkers were synthesized and have demonstrated potent tubulin polymerization inhibitory properties. Many of these novel derivatives have shown significant antiproliferative activities...

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Bibliographic Details
Main Authors: Tarek S. Ibrahim, Mohamed M. Hawwas, Azizah M. Malebari, Ehab S. Taher, Abdelsattar M. Omar, Niamh M. O’Boyle, Eavan McLoughlin, Zakaria K. Abdel-Samii, Yaseen A. M. M. Elshaier
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
combretastatin A-4
quinoline
tubulin
apoptosis
hydrazone
oxadiazole
Online Access:https://www.mdpi.com/1424-8247/13/11/393

Internet

https://www.mdpi.com/1424-8247/13/11/393

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