The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma

The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma

Abstract Background Formyl peptide receptor 2-lipoxin receptor (FPR2/ALX) modulates the anti-inflammatory response and therefore may be a target for treating sepsis. The purpose of this study was to investigate the association between genetic variants of the FPR2/ALX gene and sepsis after severe tra...

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Bibliographic Details
Main Authors: Han Zhang, Yao Lu, Guixiang Sun, Fang Teng, Nian Luo, Jianxin Jiang, Aiqing Wen
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Critical Care
Subjects:
FPR2/ALX
Promoter polymorphism
Sepsis
Severe trauma
Online Access:http://link.springer.com/article/10.1186/s13054-017-1757-3

Internet

http://link.springer.com/article/10.1186/s13054-017-1757-3

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