Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia

Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia

Epidemiological studies revealed that environmental factors comprising prenatal infection are strongly linked to risk for later development of neuropsychiatric disorders such as schizophrenia. Considering strong sex differences in schizophrenia and its increased prevalence in males, we designed a me...

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Bibliographic Details
Main Authors: Chin W. Hui, Abygaël St-Pierre, Hassan El Hajj, Yvan Remy, Sébastien S. Hébert, Giamal N. Luheshi, Lalit K. Srivastava, Marie-Ève Tremblay
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
microglia
schizophrenia
immune challenge
behavior and cognition
gene expression
electron microscopy
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00013/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00013/full

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