Asymmetric strand segregation: epigenetic costs of genetic fidelity?
Asymmetric strand segregation has been proposed as a mechanism to minimize effective mutation rates in epithelial tissues. Under asymmetric strand segregation, the double-stranded molecule that contains the oldest DNA strand is preferentially targeted to the somatic stem cell after each round of DNA...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-06-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2684645?pdf=render |