Role of <i>HMOX1</i> Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia

Role of <i>HMOX1</i> Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia

Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemo...

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Bibliographic Details
Main Authors: Karolina Bukowska-Strakova, Joanna Włodek, Ewelina Pitera, Magdalena Kozakowska, Anna Konturek-Cieśla, Maciej Cieśla, Monika Gońka, Witold Nowak, Aleksandra Wieczorek, Katarzyna Pawińska-Wąsikowska, Alicja Józkowicz, Maciej Siedlar
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
pediatric acute lymphoblastic leukemia
heme oxygenase-1
chemotherapy induced neutropenia
minimal residual disease
Online Access:https://www.mdpi.com/1422-0067/22/3/988

Internet

https://www.mdpi.com/1422-0067/22/3/988

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