Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway.

In the present study, we aim to elucidate the roles of caveolin-1(Cav-1), a 22 kDa protein in plasma membrane invaginations, in modulating neuronal differentiation of neural progenitor cells (NPCs). In the hippocampal dentate gyrus, we found that Cav-1 knockout mice revealed remarkably higher levels...

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Main Authors: Yue Li, Jianmin Luo, Wui-Man Lau, Guoqing Zheng, Shuping Fu, Ting-Ting Wang, He-Ping Zeng, Kwok-Fai So, Sookja Kim Chung, Yao Tong, Kejian Liu, Jiangang Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21826216/pdf/?tool=EBI