Columbianadin Dampens In Vitro Inflammatory Actions and Inhibits Liver Injury via Inhibition of NF-κB/MAPKs: Impacts on OH° Radicals and HO-1 Expression

Columbianadin Dampens In Vitro Inflammatory Actions and Inhibits Liver Injury via Inhibition of NF-κB/MAPKs: Impacts on OH° Radicals and HO-1 Expression

Columbianadin (CBN), a natural coumarin isolated from <i>Angelica decursiva,</i> is reported to have numerous biological activities, including anticancer and platelet aggregation inhibiting properties. Here, we investigated CBN’s anti-inflammatory effect in lipopolysaccharide (LPS)-stimu...

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Bibliographic Details
Main Authors: Thanasekaran Jayakumar, Shaw-Min Hou, Chao-Chien Chang, Tsorng-Harn Fong, Chih-Wei Hsia, Yen-Jen Chen, Wei-Chieh Huang, Periyakali Saravanabhavan, Manjunath Manubolu, Joen-Rong Sheu, Chih-Hsuan Hsia
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
columbianadin
LPS
hydroxyl radicals
HO-1 expression
liver-injury
NF-κB/MAPK signaling pathways
Online Access:https://www.mdpi.com/2076-3921/10/4/553

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https://www.mdpi.com/2076-3921/10/4/553

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