Evidence against the peroxisome proliferator-activated receptor α (PPARα) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription

Evidence against the peroxisome proliferator-activated receptor α (PPARα) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription

The glycolytic enzyme, L-pyruvate kinase (L-PK), plays an important role in hepatic glucose metabolism. Insulin and glucose induce L-PK gene expression, while glucagon and polyunsaturated fatty acids (PUFA) inhibit L-PK gene expression. We have been interested in defining the PUFA regulation of L-PK...

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Bibliographic Details
Main Authors: David A. Pan, Michelle K. Mater, Annette P. Thelen, Jeffrey M. Peters, Frank J. Gonzalez, Donald B. Jump
Format: Article
Language:English
Published: Elsevier 2000-05-01
Series:Journal of Lipid Research
Subjects:
Hepatic nuclear factor-4 (HNF4)
peroxisome proliferators
cytochrome P450 4A
glycolysis
lipogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752032383X

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http://www.sciencedirect.com/science/article/pii/S002222752032383X

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