A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects.

Previous studies have suggested that melatonin may produce antinociception through peripheral and central mechanisms. Based on the preliminary encouraging results of studies of the effects of melatonin on pain modulation, the important question has been raised of whether there is a dose relationship...

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Bibliographic Details
Main Authors: Luciana Cadore Stefani, Suzana Muller, Iraci L S Torres, Bruna Razzolini, Joanna R Rozisky, Felipe Fregni, Regina Markus, Wolnei Caumo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3788771?pdf=render