L-arginine stimulates fibroblast proliferation through the GPRC6A-ERK1/2 and PI3K/Akt pathway.

L-arginine is considered a conditionally essential amino acid and has been shown to enhance wound healing. However, the molecular mechanisms through which arginine stimulates cutaneous wound repair remain unknown. Here, we evaluated the effects of arginine supplementation on fibroblast proliferation...

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Bibliographic Details
Main Authors: Takashi Fujiwara, Shigeyuki Kanazawa, Ryoko Ichibori, Tomoko Tanigawa, Takuya Magome, Kenta Shingaki, Shingo Miyata, Masaya Tohyama, Ko Hosokawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3961283?pdf=render