Liver FOXP3 and PD1/PDL1 expression is down-regulated in chronic HBV hepatitis on maintained remission related to the degree of inflammation

Liver FOXP3 and PD1/PDL1 expression is down-regulated in chronic HBV hepatitis on maintained remission related to the degree of inflammation

Background & aim: T-cell expression of PD1 and inhibition of T effector cells by Foxp3+-T regulatory cells are among the most powerful mechanisms for achieving a balanced immune response. Our aim was to investigate, how liver FOXP3 and PD1/PDL1 expression is regulated in chronic HBV hepatiti...

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Bibliographic Details
Main Authors: Georgios eGermanidis, Nikoletta eArgentou, Prodromos eHytiroglou, Themistoklis eVassiliadis, Kalliopi ePatsiaoura, Anastasios E Germenis, Matthaios eSpeletas
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Immunology
Subjects:
Inflammation
Foxp3
regulatory T cells
chronic HBV hepatitis
PD1/PDL1
FAS/FASL
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00207/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00207/full

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