The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.

The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.

The Ikaros family of transcription factors is critical for normal T cell development while limiting malignant transformation. Mature CD8 T cells express multiple Ikaros family members, yet little is known about their function in this context. To test the functions of this gene family, we used retrov...

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Bibliographic Details
Main Authors: Eric T Clambey, Bernard Collins, Mary H Young, Jens Eberlein, Alexandria David, John W Kappler, Philippa Marrack
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3585008?pdf=render

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http://europepmc.org/articles/PMC3585008?pdf=render

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