TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified ref(2)P/p62, a key regulator of autophagy, as a potent suppressor o...

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Bibliographic Details
Main Authors: Kathleen M Cunningham, Kirstin Maulding, Kai Ruan, Mumine Senturk, Jonathan C Grima, Hyun Sung, Zhongyuan Zuo, Helen Song, Junli Gao, Sandeep Dubey, Jeffrey D Rothstein, Ke Zhang, Hugo J Bellen, Thomas E Lloyd
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
autophagy
nuclear pore
c9orf72
amyotrophic lateral sclerosis
lysosome
nucleocytoplasmic transport
Online Access:https://elifesciences.org/articles/59419

Internet

https://elifesciences.org/articles/59419

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