Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis

Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis

Objective: The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are important for the health and function of the insulin-secreting cell. Using isolated mouse, rat, and human islets, we identified the cyto...

Full description

Bibliographic Details
Main Authors: J. Jason Collier, Heidi M. Batdorf, Thomas M. Martin, Kristen E. Rohli, David H. Burk, Danhong Lu, Chris R. Cooley, Michael D. Karlstad, Joseph W. Jackson, Tim E. Sparer, Jingying Zhang, Randall L. Mynatt, Susan J. Burke
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Molecular Metabolism
Subjects:
Cytokines
Cytokine receptors
Inflammation
Pancreatic islet
Rodent
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820302143

Internet

http://www.sciencedirect.com/science/article/pii/S2212877820302143

Similar Items