Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos.

Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos.

Genetically modified mouse strains derived from embryonic stem (ES) cells have become essential tools for functional genomics and biomedical research. Large scale mutagenesis projects are producing libraries of mutant C57BL/6 (B6) ES cells to enable the functional annotation of every gene of the mou...

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Bibliographic Details
Main Authors: Marina Gertsenstein, Lauryl M J Nutter, Tammy Reid, Monica Pereira, William L Stanford, Janet Rossant, Andras Nagy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2889837?pdf=render

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http://europepmc.org/articles/PMC2889837?pdf=render

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