Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model

Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model

Abstract Quantitative in vivo monitoring of cell biodistribution offers assessment of treatment efficacy in real-time and can provide guidance for further optimization of chimeric antigen receptor (CAR) modified cell therapy. We evaluated the utility of a non-invasive, serial 89Zr-oxine PET imaging...

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Bibliographic Details
Main Authors: Naomi S. Sta Maria, Leslie A. Khawli, Vyshnavi Pachipulusu, Sharon W. Lin, Long Zheng, Daniel Cohrs, Xiaodan Liu, Peisheng Hu, Alan L. Epstein, Russell E. Jacobs
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94490-0

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https://doi.org/10.1038/s41598-021-94490-0

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