4-O-Carboxymethylascochlorin Inhibits Expression Levels of on Inflammation-Related Cytokines and Matrix Metalloproteinase-9 Through NF–κB/MAPK/TLR4 Signaling Pathway in LPS-Activated RAW264.7 Cells

4-O-Carboxymethylascochlorin Inhibits Expression Levels of on Inflammation-Related Cytokines and Matrix Metalloproteinase-9 Through NF–κB/MAPK/TLR4 Signaling Pathway in LPS-Activated RAW264.7 Cells

Toll-like receptor 4 (TLR4) and matrix metalloproteinase-9 (MMP-9) are known to play important roles in inflammatory diseases such as arteriosclerosis and plaque instability. The purpose of this study was to perform the effect of 4-O-carboxymethylascochlorin (AS-6) on MMP-9 expression in lipopolysac...

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Bibliographic Details
Main Authors: Junyoung Park, Sun-Hyung Ha, Fukushi Abekura, Hakseong Lim, Juni Magae, Ki-Tae Ha, Tae-Wook Chung, Young-Chae Chang, Young-Choon Lee, Eunyong Chung, Jiyeon Ku, Cheorl-Ho Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
AS-6
inflammation
MMP
TLR
LPS
RAW macrophage cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00304/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00304/full

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