Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging

Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging

Mouse models are vital for preclinical research on Alzheimer’s disease (AD) pathobiology. Many traditional models are driven by autosomal dominant mutations identified from early onset AD genetics whereas late onset and sporadic forms of the disease are predominant among human patients. Alongside on...

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Bibliographic Details
Main Authors: Meelim J. Lee, Chuangqi Wang, Molly J. Carroll, Douglas K. Brubaker, Bradley T. Hyman, Douglas A. Lauffenburger
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
transcriptomics
systems biology
cross-species analysis
TAM receptor agonists
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.727784/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.727784/full

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