Evaluation of gene delivery strategies to efficiently overexpress functional HLA-G on human bone marrow stromal cells

Evaluation of gene delivery strategies to efficiently overexpress functional HLA-G on human bone marrow stromal cells

Mesenchymal stromal cells (MSC) constitutively express low levels of human leukocyte antigen-G (HLA-G), which has been shown to contribute to their immunomodulatory and anti-inflammatory properties. Here, we hypothesized that overexpression of HLA-G on bone marrow-derived MSC would improve their imm...

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Bibliographic Details
Main Authors: Joana S Boura, Melisa Vance, Weihong Yin, Catarina Madeira, Cláudia Lobato da Silva, Christopher D Porada, Graça Almeida-Porada
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301097

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http://www.sciencedirect.com/science/article/pii/S2329050116301097

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