Evidence-based sizing of non-inferiority trials using decision models

Evidence-based sizing of non-inferiority trials using decision models

Abstract Background There are significant challenges to the successful conduct of non-inferiority trials because they require large numbers to demonstrate that an alternative intervention is “not too much worse” than the standard. In this paper, we present a novel strategy for designing non-inferior...

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Bibliographic Details
Main Authors: Iris Lansdorp-Vogelaar, Reshma Jagsi, Jinani Jayasekera, Natasha K. Stout, Sandra A. Mitchell, Eric J. Feuer
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Medical Research Methodology
Subjects:
Non-inferiority trial
Sample size
Power calculation
Quality-adjusted life years
Non-inferiority margin
Online Access:http://link.springer.com/article/10.1186/s12874-018-0643-2

Internet

http://link.springer.com/article/10.1186/s12874-018-0643-2

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